Patent No. 4202323 Drug activation by radiation
Patent No. 4202323 Drug activation by radiation (Zweig, et al., May 13, 1980) Abstract A method of selectively causing drug activation within a living body which comprises administering to a living body a polyamino arylmethylnitrile capable of undergoing controlled cleavage to form a polyaminoaryl methyl ion and/or a free cyanide ion, the drug also being soluble in the body serum so that it is capable of passing via oral, intramuscular or intra-peritoneal administration into a body, and then subjecting a localized area of said body to radiation capable of causing cleavage of the cyanide ion from the drug precursor, the resulting ions acting to sensitize the localized area to radiation. Notes: BACKGROUND OF THE INVENTION (1) Field of the Invention This invention relates to the in-viva activation of materials to produce drugs which act as an antitumor agent and particularly is concerned with polyarylacetonitrile